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2011

Interpenetrating polymer network of chitosan crosslinked silicone as medical implants

Author:Venkatrajah, B, Elayarajah, B, Pandidurai, V, Rajendran, R, Ajith Kumar, P and Syamili, E

Abstract:
Medical implants the most unavoidable medical device of nowadays has many potent advantages. One of the important limitations of it in medical usage is colonization of biofilm formers on the inner surface of the implants and produce high risk for the implantable material. This study involves the evaluation of one such high rate biofilm forming bacteria, Staphylococcus epidermidis which prevail in the blood. The research materials silicone used for making catheters and stents was coated with chitosan and crosslinked using poly- D,L lactic acid (PDLLA) to provide anti-bacterial activity. This was achieved through a dip coating procedure. The bioefficacy against S. epidermidis, water absorbing ability, withstanding lysozyme degradation and biocompatibility analysis were done to understand whether the coated catheters can be more advantageous than the usual one used in hospitals normally. All the analysis showed more compatible result for the chitosan-PDLLA coated catheter samples. The bioefficacy effect of the dip coated catheters and its ability to eradicate the biofilm formation on the surface designated the modified silicone catheters as efficient implants.