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2011

Monte carlo simulation of dose perturbation in different breast tissues induced by radiographic contrast inside brachytherapy balloon applicators

Author:Ali Asghar Mowlavi and Majed Yazdani

Abstract:
Background: MammoSite Radiation Therapy System with a high dose rate brachytherapy 192Ir source is used to deliver partial breast irradiation after a lumpectomy for early stage breast cancer to treat the tissue immediately surrounding the lumpectomy cavity. Materials and Methods: The spherical balloons with 4 cm to 6 cm radius have been considered filled with different mixtures of water and contrast solution in our simulation. We have used MCNP4C code to study the effect of the increased attenuation on absorbed dose value for the different glandular fraction of breast tissues. Results and discussion: We have calculated Heterogeneity Correction Factor (HCF) for various balloon diameters from 4 to 6 cm, for 0%, 20%, 50%, 70% and 100% breast glandular fraction phantom with 0%, 25%, 50%, 75% and 100% contrast concentration inside the balloon. Conclusion: The result can be used in treatment planning systems and also for computation of model dependent parameters. The calculated HCF for the Mammosite breast brachytherapy applicator are agree quite well with Clinical results which obtained by others.