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2011

Influence of Rimonabant on oral hypoglycemic activity of Glibenclamide and Glipizide on albino & diabetic rat

Author:Kaushal Patel, Bheemachari, Rajeev Kumar, Vaibhav Uplanchiwar and Sushil Raut

Abstract:
The present study was planned to study the influence of Rimonabant pretreatment (1 week) on the anti-diabetic activity of oral anti-diabetic agents in albino & Streptozotocin induced diabetic rats. Rimonabant (0.36mg/kg) & Sulfonylureas like Glibenclamide (180?g/kg) and Glipizide (270?g/kg) were administered and the time to onset of hypoglycemia, duration of the hypoglycemia & peak hypoglycemia were determined. Then Rimonabant (0.36mg/kg) was administered for 1week and on the next day 1 hour after Rimonabant treatment, the hypoglycemic effect of Sulfonylureas were evaluated. The results showed that co- administration of Rimonabant with Glipizide and Glibenclamide had positive influence on the peak hypoglycemic effect and a significant enhancement in the duration of hypoglycemic action in both normal and diabetic rats. This increased hypoglycemic activity of Glipizide and Glibenclamide after Rimonabant treatment may be due to improved insulin sensitivity and other insulin-resistant state in diabetes.